Endocrine Abstracts

Introduction: A rise in serum insulin levels during GH therapy is reported. Insulin resistance is a risk factor for type 2 diabetes, atherosclerosis, dyslipidemia, and hypertension. Few data describe insulin secretion and lipids after the end of GH therapy.Subjects and methods: Aim of our study was to evaluate changes in insulin secretion, sensitivity and lipid profile in children with isolated GHD longitudinally followed during rhGH treatment. We measur...

Introduction: A rise in serum insulin levels during GH therapy is reported. Insulin resistance is a risk factor for type 2 diabetes, atherosclerosis, dyslipidemia, and hypertension. Few data describe insulin secretion and sensitivity after the end of GH therapy in children.Methods: Aim of our study was to evaluate changes in insulin secretion and sensitivity in 24 children with isolated GHD at 3 times: i) during the last year of therapy (T0); ii) 6 month...

Introduction: The risk association between the insulin like growth factor-1 (IGF1) and cardiovascular risk is inconclusive in adults and under-explored in the pediatric population. We aimed to investigate the associations between serum concentrations of IGF1 and cardiovascular risk factors in obese children and adolescents.Methods: Cross-sectional study. Clinical and metabolic evaluations including an oral glucose tolerance test (OGTT) were performed at ...

GH has well documented insulin antagonistic effects. By inference, GHD may be expected to result in increased insulin sensitivity. Young GHD children have a tendency to both fasting and readly provoked hypoglycaemia probably resulting from impaired hormonale counter-regolation. Increased insulin sensitivity could also contribute to their hypoglycaemia; however, this has not been directly demonstrated. Interestingly, susceptibility to hypoglycaemia in GHD children diminishes wi...

Introduction: Regulation of adiponectin in GH deficiency (GHD), which presents visceral obesity, is still a matter of debate. No studies have evaluated circulating adiponectin isoforms in adult GHD subjects. Aim of this study was to evaluate total adiponectin (TA) and its isoforms (high molecular weight: HMW, medium molecular weight: MMW, low molecular weight: LMW) in hypopituitary adult subjects with and without GHD, in relation to weight, IGF1 and GH levels.<p class="abs...

The epidemic of obesity and diabetes is increased worldwide, and both are more prevalent in PCOS than non-PCOS ovulatory women. In the general population, the risk of cardiovascular mortality is at least doubled in women with extreme obesity (BMI>40 kg/m2). To explore if PCOS adds further metabolic detriment to extreme obesity, this prospective study compared the metabolic profiles, OGTT-derived insulin sensitivity and body composition between 30 adult PCOS and ...

Introduction: Higher cortisol levels and, in particular, hyperactivity of the HPA axis might play a role in the development of MS at least in adults. Data on the pediatric age are scanty.Aim of our study was to evaluate ACTH and cortisol association with MS, its components, phenotypic parameters, family history of metabolic derangements in pediatric obesity.Methods: Cross-sectional study. 271 Caucasian overweight or obese children ...

Serum IGF-I levels were measured in 547 non-hypopituitaric, non acromegalic healthy subjects of both sexes in Italy to develop reference values in relation to age and gender. Participant subjects were stratified in three age classes (25–39, 40–59 and≥60 years) and IGF-I assay was carried out by double-antibody radio immunoassay. The Pearson’s correlation coefficient between age and IGF-I values was calculated by sex and pre-defined age ranges. IGF-I levels...